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Hepadnaviridae Hepadnaviruses are the viruses in the family Hepadnaviridae . Hepadnaviruses cause liver infections in humans and animals. The best-known hepadnavirus is Hepatitis B virus.
Hepadnaviruses have very small genomes of circular, partially double-stranded DNA . They have a peculiar mode of replication, because they replicate through an RNA intermediate (which they translate back into DNA using reverse transcriptase . Because of this mode of replication, Hepadnaviruses are classified as RNA viruses.
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