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Pregnancy
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Pregnancy

Pregnancy is the process by which a mammalian female carries a live offspring from conception until it develops to the point where the offspring is capable of living outside the womb. It starts from the fertilization of an embryo (conception) to form a zygote, and ends in childbirth, miscarriage or abortion.

In humans, pregnancy takes approximately 40 weeks between the time of the last menstrual cycle and delivery. It is divided into three trimesters of three months duration each. The first trimester carries the highest risk of miscarriage, the unintentional abortion of a fetus. It is often a result of defects in the fetus, its parent, or damage caused after conception.

Euphemisms for pregnancy include 'bun in the oven', 'in a family way' and 'eating for two.'

Table of contents
1 Fertilization
2 Development
3 Delivery
4 See also:
5 External link

Fertilization

The first step of pregnancy usually begins with sexual intercourse where male gametes or sperm are deposited into the vagina. The semen produced by the male contains not only sperm cells but also sugars, proteins and other substances to help keep the sperm viable. Human sperm generally survive for about 48 hours in the female body. Sperm have a long flagellum, which they use to swim; they are the only human cells with this property. These cells are haploid, having divided by meiosis from germ cells in the testes and possessing only one half of the chromosomes of ordinary body cells. Typically, between 100 million and 300 million sperm are released in one ejaculation.

Ova, or oocytes, are the haploid female egg cells, and their role is to fuse with one sperm cell to form a fertilized zygote which will then grow in the uterus to form a developing fetus. These cells are produced by meiosis in the ovaries and stay in a state of suspended animation until activated by hormonal changes in the woman's menstrual cycle. Typically, only one ovum is released during each menstrual cycle.

At ovulation, the fimbriae at the end of the fallopian tube move over the ovary to catch the released ovum. If fertilization takes place, the sperm usually meet the ovum in the fallopian tube, requiring the sperm cells to swim from the upper vagina through the cervix and across the length of the uterus before reaching the fallopian tube—a considerable distance compared to the size of the sperm cell. Once there, the successful sperm swim towards the ovum and each attempts to fertilize it. Each sperm cell contains a small pouch of enzymes that it uses to break through the outer layer of the ovum in order to fuse with it. This can take up to twenty minutes. Once the ovum fuses with a single sperm cell, its cell membrane changes, preventing fusion with other sperm. The fusion of the ovum's and sperm's nuclei to form a diploid cell completes the first stage of pregnancy.

Alternative methods of fertilization, including artificial insemination and in vitro fertilization, are sometimes used in cases of infertility and by single women and lesbian couples.

Development

(see also Trimester)

Pre-implantation

At this point, there exists a single totipotent cell with the potential to create an entire human being. Mitotic cell division is the next process to occur, where each cell doubles to produce another diploid cell. The zygote divides to produce two smaller cells, called blastomeres, roughly every 20 hours. These cells get progressively smaller until about 4 divisions have taken place resulting in 16 individual cells. This cluster of 16 cells, called a morula, leaves the fallopian tube and makes its way to the uterus.

Ectopic pregnancy

Occasionally, the developing zygote will implant somewhere other than the uterus; this is called ectopic pregnancy. The most common location for ectopic pregnancies is in a fallopian tube, but they can arise in any tissue that the fertilized zygote can reach (essentially anywhere within the abdomen). Since only the uterus is suited to the development of the embryo, ectopic pregnancy usually results in complications when the developing embryo grows too big for the blood supply of the ectopic location to sustain it any more. When this happens, the ectopic pregnancy is at risk of rupture, potentially resulting in serious blood loss. An ectopic pregnancy can thus be a life-threatening condition.

Post-implantation

A blastocele is a small cavity on the center of the cells, and the developing cells will grow around this. There will be a flat layer of cells on the exterior of this cavity, and the zona pellucida will remain the same size as before. Cells are growing increasingly smaller to fit in. This new structure with a cavity in the center and the developing cells around it is known as a blastocyst. The presence of the blastocyst means that two types of cells are forming, inner cell mass growing on the interior of the blastocele and cells growing on the exterior of it. In 24 to 48 hours, the blastocyst's barrier, the zona pellucida breaches. The cells on the exterior of the blastocyst begin excreting an enzyme which erodes epithelial uterine lining and creates a site for implantation. The blastocyst also secretes a hormone called human chorionic gonadotropin which in turn, stimulates the corpus luteum in the mother's ovary to continue producing progesterone, which acts to maintain the lining of the uterus so that the embryo will continue to be nourished. The glands in the lining of the uterus will swell in response to the blastocyst, and capillaries will be stimulated to grow in that region. This allows the blastocyst to receive vital nutrients from the mother.

Pregnancy tests detect the presence of human chorionic gonadotropin.

Placental Circulation System

The cells surrounding the blastocyst now destroy cells in the uterine lining, forming small pools of blood which in turn stimulates the production of capillaries. This is the first stage in the growth of the placenta. The inner cell mass of the blastocyst divides rapidly, forming two layers. The top layer will become the embryo and cells from there will be used in the amniotic cavity. At the same time, the bottom layer will form a small sac. (If the cells begin developing in an abnormal position, an ectopic pregnancy may also occur at this point.) Several days later, chorionic villi in the forming placenta anchor the implantation site to the uterus. A system of blood and blood vessels now develops at the point of the newly forming placenta, growing near the implantation site. The small sac inside the blastocyst begins producing red blood cells. For the next 24 hours, connective tissue will develop between the developing placenta and the growing fetus. This will later develop into the umbilical cord.

Cellular Differentiation

Following this, a narrow line of cells appears on the surface on the embryo. Its growth shows the fetus will undergo gastrulation, in which the three layers of the fetus, the ectoderm, mesoderm and endoderm, will develop. The narrow line of cells begin to form the endoderm and mesoderm. The ectoderm begins to grow rapidly as a result of chemicals being produced by the mesoderm. These three layers will give rise to all the various types of tissue in the body.

The endoderm will later form the lining of the tongue, digestive tract, lungs, bladder and several glands. The mesoderm will form muscle, bone and lymph tissue, as well as the interior of the lungs, heart, reproductive and excretory systems. It will also give rise to the spleen, and will be used in the production of blood cells. The ectoderm will form the skin, nails, hair, cornea, lining of the internal and external ear, nose, sinuses, mouth, anus, teeth, pituitary gland, mammary glands, eyes and all parts of the nervous system.

Approximately 18 days after fertilization, the embryo has divided to form much of the tissue it will need. It is shaped like a pear, where the head region is larger than the tail. The embryo's nervous system is one of the first organs to grow. It begins growing in a concave area known as the neural groove. The blood system continues to grow networks which allow the blood to flow around the embryo. Blood cells are already being produced and are flowing through these developing networks. Secondary blood vessels also begin to develop around the placenta, to supply it with more nutrients. Blood cells will begin to form on the sac in the center of the embryo, as well as cells which will begin to differentiate into blood vessels. Endocardial cells begin to form the musculature which will become the heart.

At about 24 days past fertilization, there is a primitive S-shaped tubule heart which begins beating. The flow of fluids throughout the embryo will begin at this stage.

Organ Development

Delivery

See also:

For topics following on from a successful pregnancy and birth, see:

External link


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ParenthoodWeb's Pregnancy and Labor Corner
Pregnancy and labor information including calendars, articles, ultrasound images, ovulation predictors, journals, birth stories, chat, and discussion boards.
http://www.parenthoodweb.com/parent_cfmfiles/pregnancy_labor.cfm

Pregnancy Mate
UK community for pregnancy and baby's first year, offering a variety of interactive features and forums.
http://www.mothersbliss.com/

It's Just Another Baby
A humorous look at the stages of pregnancy from a dad's point of view.
http://www.westnet.com/~crywalt/pregnancy/contents.html

Pregnancy and Parenting Naturally
Natural alternatives to drugs in pregnancy, conception, birth and breastfeeding.
http://members.aol.com/kristachan/

BirthStories.com
Over 100 stories of labor and delivery.
http://birthstories.com

Jewish Pregnancy Online
Resource for the pregnant Jewish woman; with message board and information on traditions, prayers, tips, and art gallery on pregnancy and childbirth.
http://www.jewishpregnancy.org/

Children's Television Workshop
For new and expecting parents; provide advice on pregnancy, parenting, and baby care and nutrition.
http://babyworkshop.com/

TLContact
Helps communication among friends and family during pregnancy & delivery, hospitalization, or long-term care.
http://www.tlcontact.com

Pediatric Nutritionist
Information about feeding your children and feeding yourself during pregnancy.
http://www.parentsplace.com/expert/nutritionist/

Birth As An American Rite of Passage
Information about the rationale behind medical interventions used in hospital labor and delivery.
http://www.birthpsychology.com/messages/index.html

Expectant Mother's Guide
Expectant mothers can find pregnancy & childbirth resources in Chicago, Connecticut, Denver, Houston, Northeast New Jersey, Philadelphia, Pittsburgh, and St. Louis.
http://www.spindlepub.com/emg/index.htm

PaternityAngel
Magazine on pregnancy for both men and women. Includes due date calculators and monthly articles.
http://www.paternityangel.com/index.html

ePregnancy
From before conception to after birth, ePregnancy provides you with articles, interactive features, forums and other news, ideas and resources to keep you informed and inspired throughout your pregnant life.
http://www.epregnancy.com/

Ultimate Babies
Web directory featuring links to a variety of pregnancy, childbirth, and baby sites.
http://www.ultimatebabies.com

Nine Month Club
Tips for naming your baby, decorating the nursery, and similar information.
http://www.ninemonthclub.com/

Fetal Development Overview
The development of the embyo and fetus, with amazing color pictures.
http://www.w-cpc.org/fetal.html

Development of the Preborn Child in the Womb - Pregnancy
Photographic history of a human child from conception through all further stages of pregnancy.
http://www.silentscream.org/developm.htm

Safe Motherhood
Group dedicated to improved maternal and newborn survival. Available in English, French and Spanish.
http://www.safemotherhood.org/

The Pregnancy HelpDesk
Information and links on pregnancy, teen pregnancy, childbirth, dads links, and parenting.
http://www.geocities.com/Wellesley/1483

Alexander Technique
An explanation of the usefulness of the Alexander Technique, a century-old method of learning to release harmful stress from your body.
http://alexandertechnique.com/articles/pregnancy

The Pregnancy Centre
Helpful information about care during pregnancy.
http://thepregnancycentre.com

Communicating With Your Unborn Child
Some of the women studied found their bodies picking up their unborn babies' feelings.
http://www.innerself.com/Magazine/Parenting/communicating_with_unborn_child.htm

Canadian Parents Online
Advice, chat, and community for parents and parents to be.
http://www.canadianparents.com/

Childbirth.org
A variety of informative and personal links relating to childbirth, pregnancy, parenting, early childhood, and infant feeding.
http://www.childbirth.org/

4Pregnancy
Includes links to maternity and baby care advice as well as products for sale.
http://www.4pregnancy.com/

Pregnancy Resources at FirstBabymall.com
Review pregnancy-related articles designed to educate the first-time expectant mother while she is pregnant.
http://www.firstbabymall.com/expecting/pregnancy/resources.htm

Net Nurse
Find quality health information on pregnancy. Place questions via web-site for nurse to return a phone call to discuss your specific concerns.
http://www.netnurse.com

Pregnancy and Smoking
Pamphlet. Short. Practical advice.
http://www.ahcpr.gov/clinic/smokeprg.htm

NaturalMom.com Pregnancy
Information about herbs during pregnancy and other natural remedies.
http://www.naturalmom.com/$webmsg.list.nmpregna.1.*.listmom1r

Welcome Addition
Pregnancy calendar, nutrition, tips, month by month prenatal guide, baby's first year.
http://www.welcomeaddition.com

Dear Midwife
Discussion forum hosted by midwife Anne Sommers for expectant moms considering home birth and water birth.
http://www.dearmidwife.net

Baby's Play
Online communities and pregnancy resources.
http://www.angelfire.com/mi2/babyplay

I'm Not Too Old For Motherhood
One mom's account of a higher risk pregnancy due to advanced maternal age.
http://www.thelaboroflove.com/forum/jan/1.html

A Pregnancy Diary - by brightspot
Not your traditional pregnancy. Lots of support, informational and other helpful links.
http://www.geocities.com/kaeko_momma3

Breech Presentation
Description of the traditional Chinese method which can be used at home to encourage a breech baby to turn.
http://breech.supanet.net

Baby's Story
Offers illustrated pages and ecards to record the memorable events in the life of baby from before birth through age six.
http://www.babysstory.com

Amitys World
Natural parenting community offering discussion, chat, and articles on natural parenting, pregnancy, and childbirth.
http://www.amitysworld.com

Pregnancy and Prenatal Care
Information on signs and symptoms of pregnancy, fetal development and early stimulation of babies.
http://www.makewayforbaby.com/prenatalcare.htm

iVillage.com Pregnancy Channel
Contains various pregnancy topics, from infertility help to new baby questions, plus name ideas, baby horoscopes, interactive tools, calendars, and community discussions.
http://www.ivillage.com/topics/family/pregnancy/

Being Pregnant
A personal journey through the ins and outs of first pregnancy. Featuring a preparation list, pregnancy calendar, resources, pictures and a journal.
http://beingpregnant.tripod.com

Dancing Thru Pregnancy
Innovative programs in women's health and fitness with special emphasis on exercising safely while pregnant.
http://www.dancingthrupregnancy.com/

Teenage Pregnancy Unit
This site contains information about the work of the cross-Government Teenage Pregnancy Unit and implementation of the Government's Teenage Pregnancy Strategy.
http://www.teenagepregnancyunit.gov.uk/

Pregnancy Birth and Beyond
Up-to-date and extensive source of information and support for pregnancy, birth and parenting from an Australian perspective.
http://www.pregnancy.com.au/

Pregnancy
For expectant moms, teens, expecting multiples, birth, delivery, diapers, and article resources.
http://www.angelfire.com/md/firewoman/page5.html

A Mom's Touch
A place for first time moms to be to obtain the answers to the questions that they might be afraid of asking.
http://www.amomstouch.com

A to Z of Exercising in Pregnancy
Exercising smart and healthy from prenatal to beyond. Information and article resources.
http://www.mothersbliss.co.uk/nine/exersafeornot.htm

Family and Medical Leave (FMLA)
Survey and information site. Family leave resources, general information, statistics and an online family leave survey.
http://familyleavesurvey.homestead.com/FMLAhome.html

Babyhood Magazine
The magazine for moms-to-be with articles on pregnancy, nutrition, fitness, exercises, fashions, baby care and weight loss.
http://www.ibabyhood.com

Women's Forum - Pregnancy and Baby
A comprehensive guide to family planning and baby's first years.
http://www.womensforum.com/Pregnancy_&_Baby.html

Magic of motherhood
Experience the perfect joy of motherhood - from planning pregnancy through to the baby's first year.
http://www.mothersbliss.co.uk/index.asp

Christian-Mommies
A site for fellowship between christian mothers. Browse through a wealth of information or chat with other moms in the forums.
http://www.christian-mommies.com

Aunt Sally's Pregnant
Take this online quiz about how to have a healthy pregnancy, and learn how to prevent common birth disorders.
http://www.fasstar.com/auntsally.htm

JohnsonsBaby.com
a website for mothers providing information, tools, services, JOHNSON'S® products
http://www.johnsonsbaby.com

Sabrina's Pregnancy Page
Unlimited resources for pregnancy. Information collected by childbirth educators and expert sources of pregnancy knowledge.
http://www.fensende.com/Users/swnymph/

Pregnancy Resources @ KinderStart
List of best internet resources related to pregnancy and birth.
http://www.kinderstart.com/pregnancyandbirth/

Pregnancy: The Final Frontier
A 15-year old expectant mother's support site for pregnant teens. Includes pen pal services, resources, message board, and pregnancy and birth stories.
http://www.geocities.com/Wellesley/Garden/4085/index.html

The Vasa Previa Chat Cafe
Chat about vasa previa / velamentous cord insertion.
http://www.vasaprevia.com/coolcafe/goChat.asp

Daddy2be: Are You Ready?
So you're going to be a daddy, now what? Tips, guides, quizes, and gift ideas help prepare daddy-to-be for childbirth. Are you ready to be a Daddy2be?
http://www.family4life.com/daddy2be.htm

Robyn's Nest: The Parenting Network - Pregnancy
Information for the unborn child week-by-week, determine due date, and baby's horoscope.
http://www.robynsnest.com/preg.htm

Expectant Mothers Guide
Local and national pregnancy, childbirth, and baby related resources for expectant mothers in Brooklyn, Chicago, Connecticut, Houston, New Jersey, Pittsburgh, Philadelphia, and St. Louis.
http://www.expectantmothersguide.com

All Things Pregnant
Pregnancy information site. Articles, birth calculator, gender prediction and support from other women.
http://www.allthingspregnant.com

For Baby and Beyond
Pregnancy, parenting, and shopping information and resources. Coupons, and freebies.
http://www.forbabyandbeyond.com

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One woman's personal account from pregnancy, to labour, with tips on breastfeeding.
http://www.womanht.com/kids/baby.htm

Baby Lottery
An on-line contest where family and friends can try to predict baby's birthday.
http://www.mybabylottery.com/index.jsp

I am expecting.co.uk
The one stop shop for all parents, covering information on childbirth, childcare, parenting, nurseries and schools.
http://www.iamexpecting.co.uk/index.htm

Pregnant - What's a Birth Plan?
Los Angeles pregnancy, pregnancy information and tips. Support and help for mothers in LA.
http://www.lapregnancy.com/

Planet Info Baby
Baby and mother's health information. Articles and resources to help guide a woman through pregnancy, birth and raising a child.
http://www.geocities.com/planet_info_baby

Pregnancy Announcement Ideas
Creative and fun ways to announce a pregnancy to the family and friends.
http://www.geocities.com/pregnancyannouncement

Preparation Guide
An expectant parent's guide to preparing now before baby arrives. Also provides help for new parents sleep deprived from newborn care.
http://members.cox.net/cribsheets/cribsheets.html

The Aquanatal Register
An online directory of aquanatal exercise classes available to expectant mothers in the UK and Ireland.
http://aquanatal.co.uk

Bringing Up Baby
Guide with medical advice, focused on providing preventive health care information for new and expecting parents.
http://www.bringingupbaby.com/

BG-Mamma
Bulgarian only. A website designed by expectant and new mothers willing to share various experiences, and advise each other on the subjects of pregnancy, birth, baby and childcare.
http://www.bg-mamma.com

BabyCrowd
Community forums for discussion of all things related to expecting mothers, new mothers and experienced mothers.
http://www.babycrowd.com

Pregnancy-Info.net
Making sense of the confusing symptoms and signs of pregnancy.
http://www.pregnancy-info.net/

National Childbirth Trust - United Kingdom
Childbirth and parenting charity. Information on pregnancy, childbirth, breastfeeding, and parenthood.
http://www.nctpregnancyandbabycare.com/

Pregnancy.org
Offering online communities, interactive tools, price robot, articles and a pregnancy calendar. Content spans pre-pregnancy to after brith.
http://www.pregnancy.org

BellyBelly
A website with support from preconception to parenthood. Includes an expert panel and provides useful services and information.
http://www.bellybelly.biz

SureBaby.com
A web site for those expecting a new baby. Created by moms with regard to pregnancy, new baby concerns, baby names, due date calculator, safety concerns and shopping.
http://www.surebaby.com/

Fit Pregnancy
Your guide to having a healthy pregnancy, with expert information for moms-to-be on prenatal nutrition and fitness, baby care tips, safe exercise programs and healthy recipes.
http://www.fitpregnancy.com/

Unofficial Guide to Having a Baby
Contains excerpts from the new book, "The Unofficial Guide to Having A Baby," pregnancy articles, pregnancy links.
http://www.having-a-baby.com/



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