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Pharmacology
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Pharmacology

Pharmacology is the study of medicinal substances called pharmaceuticals. The field encompasses drug composition, drug properties, interactions, toxicology, and desirable effects that can be used in therapy of diseases.

Greek : pharmacon - drug, logos - science.

Medication drugs have to be approved by drug regulatory authorities such as the U.S. Food and Drug Administration. This field is called regulatory affairs. The International Conference on Harmonisation works in the standardisation for this.

Pharmaceuticals may be provided in a number of different pharmacological forms. Probably the most familiar are pills, in tablet and capsule form.

There are various classification systems for medicinal products including the Anatomical Therapeutic Chemical Classification System.

Classes of medicinal products

For the gastrointestinal tract or digestive system

antacid, reflux suppressant, antiflatulent, antidopaminergic, antispasmodic, proton pump inhibitor, H2 antagonists, cytoprotectant, prostaglandin analogue, laxative, antidiarrhoeal, bile acid sequestrants, opioid

For the cardiovascular system

ACE inhibitor, cardiac glycoside, phosphodiesterase inhibitor, nitrate, antianginal, antiarrhythmic, angiotensin receptor blocker, alpha blocker, beta-receptor blocker, calcium channel blocker, antihypertensive, diuretic, vasoconstrictor, vasodilator, peripheral activator, anticoagulant, heparin, antiplatelet drug, fibrinolytic, anti-hemophilic factor, haemostatic drugs, hypolipidaemic agent, statin.

For the central nervous system

hypnotic, anaesthetics, antipsychotic, antidepressant (including tricyclic antidepressants, monoamine oxidase inhibitor, lithium salt, selective serotonin reuptake inhibitor), anti-emetic, anticonvulsant and antiepileptic, anxiolytic, barbiturate, movement disorder drug, stimulant (including amphetamines), benzodiazepine, cyclopyrrolone, dopamine antagonist, antihistamine, cholinergic, anticholinergic, emetic, cannabinoids, 5-HT antagonist

For pain & consciousness (Anaesthetic drugs)

analgesics (includes acetaminophen, NSAIDs and opioids), local anesthetics, general anaesthetics, sedatives, migraine treatment drug

For musculo-skeletal disorders

NSAIDs, muscle relaxant, neuromuscular drug
anticholinesterase, COX-2 inhibitor

For the eye

anti-infective, topical antibiotic, astringent, NSAIDs, miotics, adrenergic neurone blocker, carbonic anhydrase inhibitor, ocular lubricant, mydriatic

For the ear, nose and oropharynx

sympathomimetic, antihistamine, anticholinergic, NSAIDs, steroid, antiseptic, local anesthetic, antifungal, cerumenolytic

For the respiratory system

bronchodilator, NSAIDs, anti-allergic, antitussive, mucolytic, decongestant
corticosteroid, beta-receptor antagonist, anticholinergic, steroid

For endocrine problems

androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic (sulfonylurea, biguanide/metformin, thiazolidinedione, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues

For the reproductive system or urinary system

antifungal, alkalising agent, quinolones, antibiotic, cholinergic, anticholinergic, anticholinesterase, antispasmodic, 5-alpha reductase inhibitor, selective alpha-1 blocker

For contraception

contraceptive, oral contraceptives, spermicide, depot contraceptives

For obstetrics and gynaecology

NSAIDs, anticholinergic, haemostatic drug, antifibrinolytic, Hormone Replacement Therapy, bone regulator, beta-receptor agonist, follicle stimulating hormone, luteinising hormone, LHRH
gamolenic acid, gonadotropin release inhibitor, progestogen, dopamine agonist, oestrogen, prostaglandin, gonadorelin, clomiphene, tamoxifen, Diethylstilbestrol

For the skin

emollient, anti-pruritic, antifungal, disinfectant, scabicide, pediculicide, tar products, vitamin A derivatives, vitamin D analogue, keratolytic, abrasive, systemic antibiotic, topical antibiotic, hormones, desloughing agent, exudate absorbant, fibrinolytic, proteolytic, sunscreen, antiperspirant

For infections and infestations

antibiotic, antifungal, antileprotic, antituberculous drug, antimalarial, anthelmintic, amoebicide, antiviral, antiprotozoal

For immunology

vaccine, immunoglobulin, immunosuppressant, interferon, monoclonal antibody

For allergic disorders

anti-allergic, antihistamine, NSAIDs

For nutrition

tonic, iron preparation, electrolyte, parenteral nutritional supplement, vitamins, anti-obesity drug, anabolic drug, haematopoietic drug, food product drug

For neoplastic disorders

cytotoxic drug, sex hormones, aromatase inhibitor, somatostatin inhibitor, recombinant interleukins, G-CSF, erythropoietin

For diagnostics

contrast media

For euthanasia

A euthanaticum is used for euthanasia and physician-assisted suicide, see also Barbiturate#Other_non-therapeutical_use.

Drugs found to have serious side effects and subsequently withdrawn from the market

Thalidomide (1950s-60s), diethylstilbestrol (1970s), phenformin and buformin, Fen-phen, phentermine, dexfenfluramine & fenfluramine (1997), troglitazone (2000), cerivastatin (2001), rapacuronium (ORG 9487)

See also

       


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SMR's Case Histories of Drug Discovery
Society for Medicines Research symposium on Case Histories of Drug Discvery held on December 2, 1999 in London. On demand webcast of entire symposium now available.
http://www.prous.com/smr99

Institute of Pharmacology, Polish Academy of Sciences
Information about the Institute and its neuropharmacological research, including psychotropic drugs.
http://www.if-pan.krakow.pl/

DrugInfo. Searching the Web for Drug Information
A personal Website based on 30-years experience in pharmacology. Provides help to Web browsers in locating the most relevant drug information on the Web.
http://www.drugsrnikolov.com/index.html

Cytochrome P450
Identification of a novel transcriptional silencer in the protein-coding region of the human cytochrome P450 2C9 gene.
http://drnelson.utmem.edu/CytochromeP450.html

Annual PET Pharmacokinetic Course
Course on application of PET to pharmacokinetics, open to professionals in a wide variety of fields. Held at different locations around the world, next is June 2003 in Montreal, Canada.
http://www.bic.mni.mcgill.ca/kinetics2003

Ibogaine Dossier - Bibliography of Scientific Papers
Original research and review articles on ibogaine and related subjects.
http://www.ibogaine.org/ibo-bib.html

Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico
Information on the graduate program and research activities in Pharmacology and Toxicology.
http://rcm-medicine.upr.clu.edu/pharm-tox/phar-tox.htm

Ottosen Site for Drug Safety and Pharmacovigilance
Information about drug safety and clinical studies. Includes discussion forum, news and practical information about issues like safety reporting, licensing, contracts, PSUR, E2B, electronic submission.
http://www.ottosen.com

Hardin MD - Pharmacy and Pharmacology
From the University of Iowa, lists of Internet sources in pharmacy, pharmacology, pharmaceutical, and drugs.
http://www.lib.uiowa.edu/hardin/md/pharm.html

The Virtual Clinical Pharmacologist
Access free programs to manage all aspects of anticoagulation and clinical pharmacokinetics. Multimedia medical CD-ROMs and clinical pharmacology and anticoagulation consultation are available. Multimedia medical lectures on line.
http://members.aol.com/thertch

The Ones That Stain Blue
Visionary mushrooms: studies in ethnopharmacology.
http://www.stainblue.com/ah.html

Dissolutions
The web site for answers about invitro dissolution analysis.
http://dissolutions.tripod.com/index.html

FDA Drug Approvals List
Updated weekly as a service by CDER's Division of Data Management and Services.
http://www.fda.gov/cder/da/da.htm

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
Information on research activities in Pharmacology.
http://www.pharm.unifi.it/summary.htm

Social Audit - the Antidepressant Web
Economic, medical and regulatory issues around antidepressants, esp. paroxetine withdrawal syndrome; public accountability and freedom of information; discussion pages.
http://www.socialaudit.org.uk/

Novartis Pharma
Links to Pharmacology Research Partners.
http://www.novartis-us-pharma.com/Pharmacology.htm

Medical Pharmacology
Basic and applied medical pharmacology. Includes content, practice questions and clinical cases.
http://www.pharmacology2000.com/

The Lycaeum: An Entheogenic Database
Contains a comprehensive listing of various mind altering substances, including their chemical structures and effects (with first person accounts).
http://www.lycaeum.org/

Pharmacology-Info.com
Information about pharmacology, toxicology, getting a new drug to market, and FDA approval.
http://www.pharmacology-info.com/

Toxicology-Info.com
Information on toxicology, drug interactions, toxicity and adverse reactions. Part of the ALtruis Biomedical Network.
http://www.toxicology-info.com/

Elliot Brown Consulting
MedDRA training courses, CdRom of courses available, and an online demo of MedDRA MedDicIt training.
http://www.ebconsulting.co.uk/

TICTAC
An introduction, how it is used, drug abuse and how to get further information.
http://www.tictac.org

Pharmacology and Legal Drugs - About.com
Original articles, and instructions for finding more information, about specific drugs and medications. Find new drug approvals, drug-related news, and links to additional resources, pharmacy schools and drug manufacturers.
http://pharmacology.about.com/

Institute of Pharmacology University of Bern Switzerland
Information about the institute, its history, research areas and staff.
http://www.cx.unibe.ch/pki/

Optimizing a Unimodal Response Function for Binary Variables
Adaptive sampling to locate the best dose.
http://www.eecs.umich.edu/~qstout/abs/Design2000.html

University of Colorado Health Sciences Center - Department of Pharmacology
Information about theur pharmacology graduate program, curriculum, and research activities.
http://www2.uchsc.edu/pharm/pharm.asp

New York University Department of Pharmacology
Teaching of medical and graduate students, with research programs in normal growth and differentiation, development and pathology of the nervous system, and mechanisms of normal and abnormal functions of several key hormones.
http://www.med.nyu.edu/Pharm/about.html

Body Surface Area Calculator
Calculates Body Surface Area, with advanced features such as automatic units conversion. The can be used for medication dose calculations.
http://www.halls.md/body-surface-area/bsa.htm

Laboratory of Pulmonary Pharmacology
Research in human lung, reactivity of bronchial and vascular tissues, role of the eicosanoids and the cholinergic system.
http://membres.lycos.fr/lungpharmaco/



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