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PharmacologyPharmacology is the study of medicinal substances called pharmaceuticals. The field encompasses drug composition, drug properties, interactions, toxicology, and desirable effects that can be used in therapy of diseases.
Greek : pharmacon - drug, logos - science.
Medication drugs have to be approved by drug regulatory authorities such as the U.S. Food and Drug Administration. This field is called regulatory affairs. The International Conference on Harmonisation works in the standardisation for this.
Pharmaceuticals may be provided in a number of different pharmacological forms. Probably the most familiar are pills, in tablet and capsule form.
There are various classification systems for medicinal products including the Anatomical Therapeutic Chemical Classification System.
Classes of medicinal products
antacid, reflux suppressant, antiflatulent, antidopaminergic, antispasmodic, proton pump inhibitor, H2 antagonists, cytoprotectant, prostaglandin analogue, laxative, antidiarrhoeal, bile acid sequestrants, opioid
ACE inhibitor, cardiac glycoside, phosphodiesterase inhibitor, nitrate, antianginal, antiarrhythmic, angiotensin receptor blocker, alpha blocker, beta-receptor blocker, calcium channel blocker, antihypertensive, diuretic, vasoconstrictor, vasodilator, peripheral activator, anticoagulant, heparin, antiplatelet drug, fibrinolytic, anti-hemophilic factor, haemostatic drugs, hypolipidaemic agent, statin.
hypnotic, anaesthetics, antipsychotic, antidepressant (including tricyclic antidepressants, monoamine oxidase inhibitor, lithium salt, selective serotonin reuptake inhibitor), anti-emetic, anticonvulsant and antiepileptic, anxiolytic, barbiturate, movement disorder drug, stimulant (including amphetamines), benzodiazepine, cyclopyrrolone, dopamine antagonist, antihistamine, cholinergic, anticholinergic, emetic, cannabinoids, 5-HT antagonist
analgesics (includes acetaminophen, NSAIDs and opioids), local anesthetics, general anaesthetics, sedatives, migraine treatment drug
NSAIDs, muscle relaxant, neuromuscular drug anticholinesterase, COX-2 inhibitor
For the eye
anti-infective, topical antibiotic, astringent, NSAIDs, miotics, adrenergic neurone blocker, carbonic anhydrase inhibitor, ocular lubricant, mydriatic
For the ear, nose and oropharynx
sympathomimetic, antihistamine, anticholinergic, NSAIDs, steroid, antiseptic, local anesthetic, antifungal, cerumenolytic
bronchodilator, NSAIDs, anti-allergic, antitussive, mucolytic, decongestant corticosteroid, beta-receptor antagonist, anticholinergic, steroid
androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic (sulfonylurea, biguanide/metformin, thiazolidinedione, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues
antifungal, alkalising agent, quinolones, antibiotic, cholinergic, anticholinergic, anticholinesterase, antispasmodic, 5-alpha reductase inhibitor, selective alpha-1 blocker
contraceptive, oral contraceptives, spermicide, depot contraceptives
NSAIDs, anticholinergic, haemostatic drug, antifibrinolytic, Hormone Replacement Therapy, bone regulator, beta-receptor agonist, follicle stimulating hormone, luteinising hormone, LHRH gamolenic acid, gonadotropin release inhibitor, progestogen, dopamine agonist, oestrogen, prostaglandin, gonadorelin, clomiphene, tamoxifen, Diethylstilbestrol
emollient, anti-pruritic, antifungal, disinfectant, scabicide, pediculicide, tar products, vitamin A derivatives, vitamin D analogue, keratolytic, abrasive, systemic antibiotic, topical antibiotic, hormones, desloughing agent, exudate absorbant, fibrinolytic, proteolytic, sunscreen, antiperspirant
For infections and infestations
antibiotic, antifungal, antileprotic, antituberculous drug, antimalarial, anthelmintic, amoebicide, antiviral, antiprotozoal
vaccine, immunoglobulin, immunosuppressant, interferon, monoclonal antibody
anti-allergic, antihistamine, NSAIDs
For nutrition
tonic, iron preparation, electrolyte, parenteral nutritional supplement, vitamins, anti-obesity drug, anabolic drug, haematopoietic drug, food product drug
For neoplastic disorders
cytotoxic drug, sex hormones, aromatase inhibitor, somatostatin inhibitor, recombinant interleukins, G-CSF, erythropoietin
For diagnostics
contrast media
For euthanasia
A euthanaticum is used for euthanasia and physician-assisted suicide, see also Barbiturate#Other_non-therapeutical_use.
Drugs found to have serious side effects and subsequently withdrawn from the market
Thalidomide (1950s-60s), diethylstilbestrol (1970s), phenformin and buformin, Fen-phen, phentermine, dexfenfluramine & fenfluramine (1997), troglitazone (2000), cerivastatin (2001), rapacuronium (ORG 9487)
See also
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SMR's Case Histories of Drug Discovery Society for Medicines Research symposium on Case Histories of Drug Discvery held on December 2, 1999 in London. On demand webcast of entire symposium now available. http://www.prous.com/smr99
Institute of Pharmacology, Polish Academy of Sciences Information about the Institute and its neuropharmacological research, including psychotropic drugs. http://www.if-pan.krakow.pl/
DrugInfo. Searching the Web for Drug Information A personal Website based on 30-years experience in pharmacology. Provides help to Web browsers in locating the most relevant drug information on the Web. http://www.drugsrnikolov.com/index.html
Cytochrome P450 Identification of a novel transcriptional silencer in the protein-coding region of the human cytochrome P450 2C9 gene. http://drnelson.utmem.edu/CytochromeP450.html
Annual PET Pharmacokinetic Course Course on application of PET to pharmacokinetics, open to professionals in a wide variety of fields. Held at different locations around the world, next is June 2003 in Montreal, Canada. http://www.bic.mni.mcgill.ca/kinetics2003
Ibogaine Dossier - Bibliography of Scientific Papers Original research and review articles on ibogaine and related subjects. http://www.ibogaine.org/ibo-bib.html
Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico Information on the graduate program and research activities in Pharmacology and Toxicology. http://rcm-medicine.upr.clu.edu/pharm-tox/phar-tox.htm
Ottosen Site for Drug Safety and Pharmacovigilance Information about drug safety and clinical studies. Includes discussion forum, news and practical information about issues like safety reporting, licensing, contracts, PSUR, E2B, electronic submission. http://www.ottosen.com
Hardin MD - Pharmacy and Pharmacology From the University of Iowa, lists of Internet sources in pharmacy, pharmacology, pharmaceutical, and drugs. http://www.lib.uiowa.edu/hardin/md/pharm.html
The Virtual Clinical Pharmacologist Access free programs to manage all aspects of anticoagulation and clinical pharmacokinetics. Multimedia medical CD-ROMs and clinical pharmacology and anticoagulation consultation are available. Multimedia medical lectures on line. http://members.aol.com/thertch
The Ones That Stain Blue Visionary mushrooms: studies in ethnopharmacology. http://www.stainblue.com/ah.html
Dissolutions The web site for answers about invitro dissolution analysis. http://dissolutions.tripod.com/index.html
FDA Drug Approvals List Updated weekly as a service by CDER's Division of Data Management and Services. http://www.fda.gov/cder/da/da.htm
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy Information on research activities in Pharmacology. http://www.pharm.unifi.it/summary.htm
Social Audit - the Antidepressant Web Economic, medical and regulatory issues around antidepressants, esp. paroxetine withdrawal syndrome; public accountability and freedom of information; discussion pages. http://www.socialaudit.org.uk/
Novartis Pharma Links to Pharmacology Research Partners. http://www.novartis-us-pharma.com/Pharmacology.htm
Medical Pharmacology Basic and applied medical pharmacology. Includes content, practice questions and clinical cases. http://www.pharmacology2000.com/
The Lycaeum: An Entheogenic Database Contains a comprehensive listing of various mind altering substances, including their chemical structures and effects (with first person accounts). http://www.lycaeum.org/
Pharmacology-Info.com Information about pharmacology, toxicology, getting a new drug to market, and FDA approval. http://www.pharmacology-info.com/
Toxicology-Info.com Information on toxicology, drug interactions, toxicity and adverse reactions. Part of the ALtruis Biomedical Network. http://www.toxicology-info.com/
Elliot Brown Consulting MedDRA training courses, CdRom of courses available, and an online demo of MedDRA MedDicIt training. http://www.ebconsulting.co.uk/
TICTAC An introduction, how it is used, drug abuse and how to get further information. http://www.tictac.org
Pharmacology and Legal Drugs - About.com Original articles, and instructions for finding more information, about specific drugs and medications. Find new drug approvals, drug-related news, and links to additional resources, pharmacy schools and drug manufacturers. http://pharmacology.about.com/
Institute of Pharmacology University of Bern Switzerland Information about the institute, its history, research areas and staff. http://www.cx.unibe.ch/pki/
Optimizing a Unimodal Response Function for Binary Variables Adaptive sampling to locate the best dose. http://www.eecs.umich.edu/~qstout/abs/Design2000.html
University of Colorado Health Sciences Center - Department of Pharmacology Information about theur pharmacology graduate program, curriculum, and research activities. http://www2.uchsc.edu/pharm/pharm.asp
New York University Department of Pharmacology Teaching of medical and graduate students, with research programs in normal growth and differentiation, development and pathology of the nervous system, and mechanisms of normal and abnormal functions of several key hormones. http://www.med.nyu.edu/Pharm/about.html
Body Surface Area Calculator Calculates Body Surface Area, with advanced features such as automatic units conversion. The can be used for medication dose calculations. http://www.halls.md/body-surface-area/bsa.htm
Laboratory of Pulmonary Pharmacology Research in human lung, reactivity of bronchial and vascular tissues, role of the eicosanoids and the cholinergic system. http://membres.lycos.fr/lungpharmaco/
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